Drug Parameters Important for Transdermal Delivery

Research focus: Biological, physicochemical, and pharmacokinetic criteria
Original source: https://stacks.cdc.gov/view/cdc/243468

Why it matters

A CDC/NIOSH-hosted review of the criteria used to decide whether a substance is a plausible transdermal drug.

Key points

Biological activity, physicochemical properties, and pharmacokinetics all matter.
Skin uptake is not the same as useful systemic delivery; cutaneous metabolism may inactivate a compound.
The relevant sequence includes partitioning, diffusion, transfer into viable tissue, and uptake by cutaneous microcirculation.

Scope note: This is a research brief, not medical advice. It does not establish that soil minerals are nutritionally absorbed through intact skin.

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