Physicochemical Aspects of Percutaneous Penetration and Its Enhancement

Research focus: Partitioning, diffusion, and enhancement mechanisms
Original source: https://stacks.cdc.gov/view/cdc/224103

Why it matters

A CDC/NIOSH-hosted review focused on physicochemical factors controlling percutaneous penetration and methods for enhancing it.

Key points

A compound must partition into the stratum corneum and then diffuse through it.
Vehicle composition and oil/water partition behavior strongly influence flux.
Enhancement is not automatically beneficial: increasing penetration can also increase exposure risk.

Scope note: This is a research brief, not medical advice. It does not establish that soil minerals are nutritionally absorbed through intact skin.

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