Percutaneous absorption in diseased skin: an overview

Research focus: Disease, abrasion, heat, irritation, and permeability
Original source: https://pubmed.ncbi.nlm.nih.gov/22912973

Why it matters

A review of how disease and experimentally induced changes in the stratum corneum alter percutaneous penetration.

Key points

Tape stripping, heat, surfactants, and some forms of irritation can alter permeability.
Effects depend on the compound: hydrophilic and lipophilic substances do not respond identically.
This is a useful caution against treating “skin absorption” as one uniform process.

Scope note: This is a research brief, not medical advice. It does not establish that soil minerals are nutritionally absorbed through intact skin.

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