Barrier function of intact and impaired skin: percutaneous penetration of caffeine and salicylic acid

Research focus: Experimental barrier disruption and permeability
Original source: https://pubmed.ncbi.nlm.nih.gov/21699529

Why it matters

An experimental study using intact and progressively stripped skin to examine caffeine and salicylic-acid penetration.

Key points

Barrier disruption increased penetration in the tested model.
The magnitude and pattern of the change depended on the test compound’s hydrophilic/lipophilic balance.
It provides a concrete experimental example of why scratches and damaged skin can change exposure.

Scope note: This is a research brief, not medical advice. It does not establish that soil minerals are nutritionally absorbed through intact skin.

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