Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum

Research focus: Stratum corneum, enhancers, microneedles, and delivery limits
Original source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695828

Why it matters

An open-access review of transdermal drug delivery and strategies for overcoming the stratum-corneum barrier.

Key points

The stratum corneum is the principal barrier to most transdermal delivery.
Successful passive delivery generally favors small molecules with suitable oil/water partitioning and solubility.
Chemical enhancers, microneedles, electroporation, and ablation can expand what crosses the barrier, but they also change safety and infection considerations.

Scope note: This is a research brief, not medical advice. It does not establish that soil minerals are nutritionally absorbed through intact skin.

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